Links to Further Information About OPT Technology:
Original Publications
Review Articles
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Wellcome Award
Original publications about OPT technology;
- Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
Science. 2002 Apr 19;296(5567):541-5.
Sharpe J et al
- Correction of artefacts in optical projection tomography.
Phys Med Biol. 2005 Oct 7;50(19):4645-65.
Walls JR, Sled JG, Sharpe J, Henkelman RM.
- Resolution improvement in emission optical projection tomography
Johnathon R Walls, John G Sled, James Sharpe, R Mark Henkelman
Phys. Med. Biol. 52 2775-2790 2007
- In vitro whole-organ imaging: 4D quantification of growing mouse limb buds.
Marit J Boot, C Henrik Westerberg, Juanjo Sanz-Ezquerro, James Cotterell, Ronen Schweitzer, Miguel Torres & James Sharpe
Nature Methods - 5, 609 - 612 (2008)
- Live optical projection tomography.
Colas JF, Sharpe J.
Organogenesis. 2009 Oct;5(4):211-6.
- Optical projection tomography of vertebrate embryo development.
Quintana L, Sharpe J.
Cold Spring Harb Protoc. 2011 Jun 1;2011(6).
- Preparation of mouse embryos for optical projection tomography imaging.
Quintana L, Sharpe J.
Cold Spring Harb Protoc. 2011 Jun 1;2011(6):664-9. doi: 10.1101/pdb.prot5639. No abstract available
- Image Processing Assisted Algorithms for Optical Projection Tomography.
Cheddad A, Svensson C, Sharpe J, Georgsson F, Ahlgren U.
IEEE Trans Med Imaging. 2011 Jul 14. [Epub ahead of print]
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Original publications using OPT technology;
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- Embryonic and neonatal phenotyping of genetically engineered mice.
ILAR J. 2006;47(2):103-17.
Kulandavelu S et al
- Molecular pathogenesis of autosomal dominant polycystic kidney disease.
Expert Rev Mol Med. 2006 Jan 17;8(2):1-22.
Yoder et al
Link to movie http://www-ermm.cbcu.cam.ac.uk/06010453h.htm
- FGF signalling controls expression of vomeronasal receptors during embryogenesis.
Mech Dev. 2006 Jan;123(1):17-23
Oleg Lioubinski et al
- Cardiac malformations and midline skeletal defects in mice lacking filamin A
Human Molecular Genetics 2006 15(16):2457-2467
Alan W. Hart et al
- Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1–/– mice
Genes & Development 20:2208-2213, 2006
Amir Asayesh, James Sharpe, Robert P. Watson, Jacob Hecksher-Sørensen, Nicholas D. Hastie, Robert E. Hill and Ulf Ahlgren
- Visualizing Plant Development and Gene Expression in Three Dimensions Using Optical Projection Tomography.
Plant Cell. August 11, 2006; 10.1105/tpc.106.043042
Karen Lee et al
- The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis.
Development 2006 133: p. 3723-3732
Ugo Borello et al
- Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart
Development 2006 133: p. 4595-4606
Risebro, C. A., Smart, N., Dupays, L., Breckenridge, R., Mohun, T.J., Riley, P. R.
- Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb.
Dev Biol. 2006 Nov 1;299(1):22-34.
DeLaurier A, Schweitzer R, Logan M.
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Three-dimensional imaging of whole rodent organs using optical computed and emission tomography.
J Biomed Opt. 2007 Jan-Feb;12(1):014009.
Oldham M, Sakhalkar H, Wang YM, Guo P, Oliver T, Bentley R, Vujaskovic Z, Dewhirst M.
- Tomographic molecular imaging and 3D quantification within adult mouse organs.
Nat Methods. 2007 Jan;4(1):31-3.
Alanentalo T, Asayesh A, Morrison H, Loren CE, Holmberg D, Sharpe J, Ahlgren U.
- Expression of Plxdc2/TEM7R in the developing nervous system of the mouse.
Gene Expr Patterns. 2007 Apr;7(5):635-44.
Miller SF, Summerhurst K, Runker AE, Kerjan G, Friedel RH, Chedotal A, Murphy P, Mitchell KJ
- Pan-myocardial expression of Cre recombinase throughout mouse development.
Genesis. 2007 Mar;45(3):135-44.
Breckenridge R, Kotecha S, Towers N, Bennett M, Mohun T.
- Three-dimensional imaging of Drosophila melanogaster.
McGurk L, Morrison H, Keegan LP, Sharpe J, O'Connell MA.
PLoS ONE. 2007 Sep 5;2(9):e834.
- Visualizing expression patterns of Shh and Foxf1 genes in the foregut and lung buds by optical projection tomography
Sato H, Murphy P, Giles S, Bannigan J, Takayasu H, Puri P.
Pediatr Surg Int. 2007 Oct 26
- Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme
Carlos G. Arques, Roisin Doohan, James Sharpe and Miguel Torres
Development. 2007 Oct;134(20):3713-22. Epub 2007 Aug 22.
- A dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones
Nowlan NC , Murphy P, Prendergast PJ.
J Biomech. 2007 Nov 13
- Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis.
Ijpenberg A, Pérez-Pomares JM, Guadix JA, Carmona R, Portillo-Sánchez V, Macías D, Hohenstein P, Miles CM, Hastie ND, Muñoz-Chápuli R.
Dev Biol. 2007 Sep 18
- Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme .
Carlos G. Arques, Roisin Doohan, James Sharpe and Miguel Torres
Development. 2007 Oct;134(20):3713-22. Epub 2007 Aug 22
- Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.
Kenta Yashiro, Hidetaka Shiratori& Hiroshi Hamada
Nature. 2007 Nov 8;450(7167):285-8.
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- EMAGE--Edinburgh Mouse Atlas of Gene Expression: 2008 update.
Shanmugasundaram Venkataraman, Peter Stevenson, Yiya Yang,
Lorna Richardson, Nicholas Burton, Thomas P. Perry, Paul Smith,
Richard A. Baldock, Duncan R. Davidson and Jeffrey H. Christiansen
Nucleic Acids Res. 2008 Jan;36(Database issue):D860-5
- Visualizing expression patterns of Shh and Foxf1 genes in the foregut and lung buds by optical projection tomography
Sato H, Murphy P, Giles S, Bannigan J, Takayasu H, Puri P.
Pediatr Surg Int. 2008 Jan;24(1):3-11
- Integrating technologies for comparing 3D gene expression domains in the developing chick limb.
Malcolm E. Fisher, Allyson K. Clelland, Andrew Bain, Richard A. Baldock, Paula Murphy, Helen Downie, Cheryll Tickle, Duncan R. Davidson and Richard A. Buckland
Dev Biol. 2008 Feb 7
- Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography.
J Biomed Opt. 2008 Mar-Apr;13(2):021113.
Oldham M, Sakhalkar H, Oliver T, Allan Johnson G, Dewhirst M.
- Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis.
Mohammad K. Hajihosseini, Stijn De Langhe, Eva Lana-Elola, Harris Morrison, Neil Sparshotta, Robert Kelly, James Sharpe, David Rice and Saverio Bellusci
Mol Cell Neurosci. 2008 Apr;37(4):857-68.
- 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19)
Kristen Summerhurst, Margaret Stark, James Sharpe, Duncan Davidson and Paula Murphy
Gene Expr Patterns. 2008 May;8(5):331-48
- Integrating technologies for comparing 3D gene expression domains in the developing chick limb.
Malcolm E. Fisher, Allyson K. Clelland, Andrew Bain, Richard A. Baldock, Paula Murphy, Helen Downie, Cheryll Tickle, Duncan R. Davidson and Richard A. Buckland
Dev Biol. 2008 Feb 7 (Epub ahead of print)
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- Human-Specific Gain of Function in a Developmental Enhancer
Prabhakar S, Visel A, Akiyama JA, Shoukry M, Lewis KD, Holt A, Plajzer-Frick I, Morrison H, Fitzpatrick DR, Afzal V, Pennacchio LA, Rubin EM, Noonan JP.
Science. 2008 Sep 5;321(5894):1346-50
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Three-Dimensional Analysis of Vascular Development in the Mouse Embryo
Johnathon R. Walls, Leigh Coultas, Janet Rossant, and R. Mark Henkelman
PLoS ONE. 2008 Aug 6;3(8):e2853.
- The Mouse LImb Anatomy Atlas: An interactive 3D tool for studying embryonic limb patterning
Delaurier A, Burton N, Bennett M, Baldock R, Davidson D, Mohun TJ, Logan MP.
BMC Dev Biol. 2008 Sep 15;8:83.
- High-resolution three-dimensional imaging of islet-infiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas.
Alanentalo T, Lorén CE, Larefalk A, Sharpe J, Holmberg D, Ahlgren U.
J Biomed Opt. 2008 Sep-Oct;13(5):054070.
- Fluorescence lifetime optical projection tomography.
McGinty J, Tahir KB, Laine R, Talbot CB, Dunsby C, Neil MA, Quintana L, Swoger J, Sharpe J, French PM.
J Biophotonics. 2008 Oct;1(5):390-4
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- Normalized Born ratio for fluorescence optical projection tomography.
Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R.
Opt Lett. 2009 Feb 1;34(3):319-21.
- Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein.
Yu T, Fotaki V, Mason JO, Price DJ.
J Comp Neurol. 2009 Feb 10;512(5):613-27.
- Born normalization for fluorescence optical projection tomography for whole heart imaging.
Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R.
J Vis Exp. 2009 Jun 2;(28). pii: 1389
- Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.
Vendrell V, Summerhurst K, Sharpe J, Davidson D, Murphy P.
Gene Expr Patterns. 2009 Jun;9(5):296-305
- Genetic background influences embryonic lethality and the occurrence of neural tube defects in Men1 null mice: relevance to genetic modifiers.
Lemos M, Harding B, Reed A, Jeyabalan J, Walls G, Bowl M, Sharpe J, Wedden S, Moss J, Ross A, Davidson D, Thakker R.
J Endocrinol. 2009 Jul 8
- Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice.
Sato H, Murphy P, Hajduk P, Takayasu H, Kitagawa H, Puri P.
Pediatr Surg Int. 2009 Aug 19
- Fgf10 gene expression is delayed in the embryonic lung mesenchyme in the adriamycin mouse model.
Hajduk P, Murphy P, Puri P.
Pediatr Surg Int. 2009 Oct 24
- Dual-modal three-dimensional imaging of single cells with isometric high resolution using an optical projection tomography microscope.
Miao Q, Rahn JR, Tourovskaia A, Meyer MG, Neumann T, Nelson AC, Seibel EJ.
J Biomed Opt. 2009 Nov-Dec;14(6)
- High throughput transmission optical projection tomography using low cost graphics processing unit.
Vinegoni C, Fexon L, Feruglio PF, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R.
Opt Express. 2009 Dec 7;17(25):22320-32
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- From spatial-data to 3D models of the developing human brain.
Wang X, Lindsay S, Baldock R.
Methods. 2010 Feb;50(2):96-104. Epub 2009 Oct 1
- Mesenchymal expression of Tbx4 gene is not altered in Adriamycin mouse model.
Hajduk P, Murphy P, Puri P.
Pediatr Surg Int. 2010 Feb 25. [Epub ahead of print]
- Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway.
Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C, Ludewig B, Stein JV.
Blood. 2010 Feb 25. [Epub ahead of print]
- Tomographic quantification of branching morphogenesis and renal development.
Short KM, Hodson MJ, Smyth IM.
Kidney Int. 2010 Mar 3. [Epub ahead of print]
- Quantification and 3-D imaging of the insulitis-induced destruction of {beta}-cells in murine Type 1 Diabetes.
Alanentalo T, Hörnblad A, Mayans S, Nilsson AK, Sharpe J, Larefalk A, Ahlgren U, Holmberg D.
Diabetes. 2010 Apr 14. [Epub ahead of print]
- Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.
Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R.
Opt Lett. 2010 Apr 1;35(7):1088-90.
- Dual-mode optical projection tomography microscope using gold nanorods and hematoxylin-stained cancer cells.
Miao Q, Yu J, Rahn JR, Meyer MG, Neumann T, Nelson AC, Seibel EJ.
Opt Lett. 2010 Apr 1;35(7):1037-9.
- Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.
Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA.
Diabetologia. 2010 May;53(5):924-36. Epub 2010 Mar 11.
- Correction for specimen movement and rotation errors for in-vivo Optical Projection Tomography.
Birk UJ, Rieckher M, Konstantinides N, Darrell A, Sarasa-Renedo A, Meyer H, Tavernarakis N, Ripoll J.
Biomed Opt Express. 2010 Jul 14;1(1):87-96.
- Time-gated optical projection tomography.
Bassi A, Brida D, D'Andrea C, Valentini G, Cubeddu R, De Silvestri S, Cerullo G.
Opt Lett. 2010 Aug 15;35(16):2732-4. doi: 10.1364/OL.35.002732.
- Block matching 3D random noise filtering for absorption optical projection tomography.
Fumene Feruglio P, Vinegoni C, Gros J, Sbarbati A, Weisleder R.
Phys Med Biol. 2010 Sep 21;55(18):5401-15. Epub 2010 Aug 25.
- Contrast and resolution analysis of iterative angular domain optical projection tomography.
Ng E, Vasefi F, Kaminska B, Chapman GH, Carson JJ.
Opt Express. 2010 Sep 13;18(19):19444-55. doi: 10.1364/OE.18.019444.
- Resolution improvement in optical projection tomography by the focal scanning method.
Miao Q, Hayenga J, Meyer MG, Neumann T, Nelson AC, Seibel EJ.
Opt Lett. 2010 Oct 15;35(20):3363-5. doi: 10.1364/OL.35.003363.
- The HUDSEN Atlas: a three-dimensional (3D) spatial framework for studying gene expression in the developing human brain.
Kerwin J, Yang Y, Merchan P, Sarma S, Thompson J, Wang X, Sandoval J, Puelles L, Baldock R, Lindsay S.
J Anat. 2010 Oct;217(4):289-99. doi: 10.1111/j.1469-7580.2010.01290.x.
- Embryonic Wnt gene expression in the nitrofen-induced hypoplastic lung using 3-dimensional imaging.
Takayasu H, Murphy P, Sato H, Doi T, Puri P.
J Pediatr Surg. 2010 Nov;45(11):2129-35.
- The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.
Freem LJ, Escot S, Tannahill D, Druckenbrod NR, Thapar N, Burns AJ.
J Anat. 2010 Dec;217(6):651-64. doi: 10.1111/j.1469-7580.2010.01295.x. Epub 2010 Sep 14.
- Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
Jurado S, Smyth I, van Denderen B, TenisN, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J.
PLoS Genet. 2010 Oct 21;6(10):e1001170.
- Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.
Development. 2010 Aug 1;137(15):2559-69.
Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V.
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- Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint.
Roddy KA, Kelly GM, van Es MH, Murphy P, Prendergast PJ.
J Biomech. 2011 Jan 4;44(1):143-9. Epub 2010 Sep 29.
- Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency.
Roszer T, Menéndez-Gutiérrez MP, Lefterova MI, Alameda D, Núñez V, Lazar MA, Fischer T, Ricote M.
J Immunol. 2011 Jan 1;186(1):621-31. Epub 2010 Dec 6
- NOA1 is an essential GTPase required for mitochondrial protein synthesis.
Kolanczyk M, Pech M, Zemojtel T, Yamamoto H, Mikula I, Calvaruso MA, van den Brand M, Richter R, Fischer B, Ritz A, Kossler N, Thurisch B, Spoerle R, Smeitink J, Kornak U, Chan D, Vingron M, Martasek P, Lightowlers RN, Nijtmans L, Schuelke M, Nierhaus KH, Mundlos S.
Mol Biol Cell. 2011 Jan 1;22(1):1-11. Epub 2010 Nov 30.
- Quantitative 3-dimensional imaging of murine neointimal and atherosclerotic lesions by optical projection tomography.
Kirkby NS, Low L, Seckl JR, Walker BR, Webb DJ, Hadoke PW.
PLoS One. 2011 Feb 17;6(2):e16906.
- Improved reconstructions and generalized filtered back projection for optical projection tomography.
Birk UJ, Darrell A, Konstantinides N, Sarasa-Renedo A, Ripoll J.
Appl Opt. 2011 Feb 1;50(4):392-8. doi: 10.1364/AO.50.000392.
- Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.
Berry R, Harewood L, Pei L, Fisher M, Brownstein D, Ross A, Alaynick WA, Moss J, Hastie ND, Hohenstein P, Davies JA, Evans RM, FitzPatrick DR.
Hum Mol Genet. 2011 Mar 1;20(5):917-26. Epub 2010 Dec 6.
- A landmark-free morphometric staging system for the mouse limb bud.
Boehm B, Rautschka M, Quintana L, Raspopovic J, Jan Z, Sharpe J.
Development. 2011 Mar;138(6):1227-34. Epub 2011 Feb 9.
- Highly efficient 3D fluorescence microscopy with a scanning laser optical tomograph.
Lorbeer RA, Heidrich M, Lorbeer C, Ramírez Ojeda DF, Bicker G, Meyer H, Heisterkamp A.
Opt Express. 2011 Mar 14;19(6):5419-30. doi: 10.1364/OE.19.005419.
- N-myc controls proliferation, morphogenesis, and patterning of the inner ear.
Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T.
J Neurosci. 2011 May 11;31(19):7178-89.
- The podocyte protein nephrin is required for cardiac vessel formation.
Hum Mol Genet. 2011 Jun 1;20(11):2182-94. Epub 2011 Mar 14.
Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD.
- 3-Dimensional Imaging Modalities for Phenotyping Genetically Engineered Mice.
Powell KA, Wilson D.
Vet Pathol. 2011 Dec 6
- Secreted BMP Antagonist, Cer1, Fine Tunes the Spatial Organization of the Ureteric Bud Tree during Mouse Kidney Development.
Chi L, Saarela U, Railo A, Prunskaite-Hyyryläinen R, Skovorodkin I, Anthony S, Katsu K, Liu Y, Shan J, Salgueiro AM, Belo JA, Davies J, Yokouchi Y, Vainio SJ.
PLoS One. 2011;6(11):e27676. Epub 2011 Nov 17.
- Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture.
Leeper AD, Farrell J, Williams LJ, Thomas JS, Michael Dixon J, Wedden SE, Harrison DJ, Katz E.
Biomaterials. 2012 Jan;33(3):907-15. Epub 2011 Nov 1.
- Multimodal 3D Imaging of Cells and Tissue, Bridging the Gap Between Clinical and Research Microscopy.
Miao Q, Reeves AP, Patten FW, Seibel EJ.
Ann Biomed Eng. 2011 Oct 8. [Epub ahead of print]
- Nephron formation adopts a novel spatial topology at cessation of nephrogenesis.
Rumballe BA, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH.
Dev Biol. 2011 Dec 1;360(1):110-22. Epub 2011 Sep 21
- MicroCT for molecular imaging: quantitative visualization of complete three-dimensional distributions of gene products in embryonic limbs.
Metscher BD, Müller GB.
Dev Dyn. 2011 Oct;240(10):2301-8. doi: 10.1002/dvdy.22733. Epub 2011 Sep 7.
- Long-term culture of human breast cancer specimens and their analysis using optical projection tomography.
Leeper AD, Farrell J, Dixon JM, Wedden SE, Harrison DJ, Katz E.
J Vis Exp. 2011 Jul 29;(53). pii: 3085. doi: 10.3791/3085.
- Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas.
Hörnblad A, Eriksson AU, Sock E, Hill RE, Ahlgren U.
PLoS One. 2011;6(6):e21753. Epub 2011 Jun 30.
- Msx genes define a population of mural cell precursors required for head blood vessel maturation.
Lopes M, Goupille O, Saint Cloment C, Lallemand Y, Cumano A, Robert B.
Development. 2011 Jul;138(14):3055-66.
- An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution.
Hörnblad A, Cheddad A, Ahlgren U.
Islets. 2011 Jul-Aug;3(4):204-8. Epub 2011 Jul 1.
- Three-dimensional ex vivo imaging and analysis of intraportal islet transplants.
Fujimoto H, Toyoda K, Okitsu T, Liu X, Mukai E, Zhuang X, Uemoto S, Mochizuki N, Inagaki N.
Transpl Int. 2011 Aug;24(8):839-44. doi: 10.1111/j.1432-2277.2011.01271.x. Epub 2011 May 25
- Comparative analysis of 3D expression patterns of transcription factor genes and digit fate maps in the developing chick wing.
Fisher M, Downie H, Welten MC, Delgado I, Bain A, Planzer T, Sherman A, Sang H, Tickle C.
PLoS One. 2011 Apr 22;6(4):e18661.
- 3D expression patterns of cell cycle genes in the developing chick wing and comparison with expression patterns of genes implicated in digit specification.
Welten M, Pavlovska G, Chen Y, Teruoka Y, Fisher M, Bangs F, Towers M, Tickle C.
Dev Dyn. 2011 May;240(5):1278-88. doi: 10.1002/dvdy.22633
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Review articles about OPT technology;
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Review articles citing OPT technology;
- Molecular imaging of the embryonic heart: Fables and facts on 3D imaging of gene expression patterns.
Birth Defects Res C Embryo Today. 2004 Sep;72(3):224-40. Review.
Ruijter JM, Soufan AT, Hagoort J, Moorman AF.
- The contribution of chicken embryology to the understanding of vertebrate limb development.
Mechanisms of Development 121 (2004) 1019-1029
C Tickle.
- Imaging: The Big Picture
Nature 2005; 437: 775- 779
Lisa Melton
- MRC-Wellcome Trust Human Developmental Biology Resource: enabling studies of human developmental gene expression.
Lindsay S, Copp AJ.
Trends Genet. 2005 Nov;21(11):586-90. Epub 2005 Sep 9. Review.
- Endothelial cells and VEGF in vascular development.
Nature. 2005 Dec 15;438(7070):937-45. Review.
Coultas L, Chawengsaksophak K, Rossant J.
- An illustrated review of early pancreas development in the mouse.
Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.
Endocr Rev. 2007 Oct;28(6):685-705. Epub 2007 Sep 19.
- The anatomy of organogenesis: Novel solutions to old problems.
Prog Histochem Cytochem. 2006;40(3):165-76.
Davies JA, Armstrong JE.
- Multimodal imaging of mouse development: Tools for the postgenomic era.
Dev Dyn. 2006 Sep;235(9):2386-400.
Dickinson, M.E.
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