Approaches to Understand the Immunobiology of Human Immunodeficiency Virus Latency

bioptonics

Widespread Denominators within the Immunobiology of IgG4 Autoimmune Illnesses: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Widespread?

IgG4 autoimmune illnesses (IgG4-AID) are an rising group of autoimmune illnesses which can be brought on by pathogenic autoantibodies of the IgG4 subclass. It has solely not too long ago been appreciated, that members of this group share related immunobiological and therapeutic elements despite the fact that completely different antigens, tissues and organs are affected: glomerulonephritis (kidney), pemphigus vulgaris (pores and skin), thrombotic thrombocytopenic purpura (hematologic system) muscle-specific kinase (MuSK) in myasthenia gravis (peripheral nervous system) and autoimmune encephalitis (central nervous system) to present some examples.

In all these illnesses, sufferers’ IgG4 subclass autoantibodies block protein-protein interactions as a substitute of inflicting complement mediated tissue harm, sufferers reply favorably to rituximab and share a genetic predisposition: at the least 5 HLA class II genes have been reported in particular person research to be related to a number of completely different IgG4-AID.

This implies a task for the HLA class II area and particularly the DRβ1 chain for aberrant priming of autoreactive T-cells towards a continual immune response skewed towards the manufacturing of IgG4 subclass autoantibodies.

The intention of this assessment is to offer an replace on findings arguing for a standard pathogenic mechanism in IgG4-AID in basic and to offer hypotheses in regards to the function of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID.

Modular Approaches to Perceive the Immunobiology of Human Immunodeficiency Virus Latency

Regardless of advances in slowing the development of acquired immunodeficiency syndrome (AIDS), there isn’t a viable treatment for human immunodeficiency virus (HIV). The problem towards a treatment is especially the formation and upkeep of a latent reservoir of cells that harbor the virus in each replication-competent and replication-defective states.

This small area of interest of quiescent cells has been recognized to reside primarily in quiescent and reminiscence CD4+ T cells, however parameters that might reliably distinguish an contaminated T cell from an uninfected one, if any, will not be clear. As well as, the migratory properties and particular anatomical reservoirs of latent T cells are troublesome to measure at a excessive decision in people. A practical treatment of HIV would require concentrating on this inhabitants utilizing modern new medical methods.

One constraint towards the empirical improvement of such approaches is the absence of a local small animal mannequin for AIDS. Since HIV doesn’t effectively infect murine cells, probing molecular-genetic questions involving latently contaminated T cells homing to deep tissue websites, interacting with stroma and persisting by completely different remedy regimens, is difficult.

The objective of this text is to debate how inspecting the dynamics of T cells in mouse fashions can present a framework for successfully learning these questions, even with out infecting mice with HIV. The inflammatory and cytokine milieu present in early human HIV infections are being more and more understood on account of medical measurements.

Mouse research that recreate this milieu can doubtlessly be used to subsequently map the destiny of T cells activated on this context in addition to their migratory routes. In essence, such a framework may permit complementary research in mice to boost our understanding of elements of the biology of HIV latency. This may be the idea of a modular method to small animal HIV modeling, amenable to preclinical healing technique improvement.

bioptonics
bioptonics

Cdc42 Activation Assay

STA-402 20 assays
EUR 908.4
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay

STA-403-A 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay

STA-403-B 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay

STA-403-C 20 assays
EUR 908.4
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Arf1 Activation Assay

STA-407-1 20 assays
EUR 908.4
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay

STA-407-6 20 assays
EUR 908.4
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay

STA-408 20 assays
EUR 908.4
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay

STA-409 20 assays
EUR 908.4
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

Pan-RAS-IN-1

HY-101295 25mg
EUR 2043.6

Rap1 Activation Assay Kit

STA-406-1 20 assays
EUR 908.4
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit

STA-406-2 20 assays
EUR 908.4
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rac1 Activation Assay Kit, Trial Size

STA-401-1-T 5 assays
EUR 483.6
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rac2 Activation Assay Kit, Trial Size

STA-401-2-T 5 assays
EUR 483.6
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Cdc42 Activation Assay Kit, Trial Size

STA-402-T 5 assays
EUR 483.6
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay Kit, Trial Size

STA-403-A-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay Kit, Trial Size

STA-403-B-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay Kit, Trial Size

STA-403-C-T 5 assays
EUR 483.6
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Rac1/Cdc42 Activation Assay Combo Kit

STA-404 2 x 20 assays
EUR 1305.6
Description: Our Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Rap1 Activation Assay Kit, Trial Size

STA-406-1-T 5 assays
EUR 483.6
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit, Trial Size

STA-406-2-T 5 assays
EUR 483.6
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Arf1 Activation Assay Kit, Trial Size

STA-407-1-T 5 assays
EUR 483.6
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay Kit, Trial Size

STA-407-6-T 5 assays
EUR 483.6
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay Kit, Trial Size

STA-408-T 5 assays
EUR 483.6
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay Kit, Trial Size

STA-409-T 5 assays
EUR 483.6
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

96-Well Ras Activation ELISA Kit (Colorimetric)

STA-440 96 assays
EUR 1082.4
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

96-Well Ras Activation ELISA Kit (Chemiluminescent)

STA-441 96 assays
EUR 1082.4
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

RhoA/Rac1/CDC42 Activation Assay Combo Kit

STA-405 3 x 10 assays
EUR 1305.6
Description: Our RhoA/Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Pan-PAX (Pan-PAX) Antibody

abx236136-100ug 100 ug
EUR 577.2

Rabbit Anti-Mouse IgG, Antisera (Bulk)

44319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Goat IgG, Antisera (Bulk)

60319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Human IgG, Antisera (Bulk)

10119-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Llama IgG (H+L chain), Antisera (Bulk)

30818-RAS-BLK 1-10L, bulk Ask for price

Ras Antibody

48578-100ul 100ul
EUR 399.6

Ras Antibody

48578-50ul 50ul
EUR 286.8

Ras Antibody

48602-100ul 100ul
EUR 399.6

Ras Antibody

48602-50ul 50ul
EUR 286.8

Ras Antibody

49408-100ul 100ul
EUR 399.6

Ras Antibody

49408-50ul 50ul
EUR 286.8

RAS Antibody

31153-100ul 100ul
EUR 302.4

RAS Antibody

31153-50ul 50ul
EUR 224.4

RAS antibody

10R-1779 100 ul
EUR 418.8
Description: Mouse monoclonal RAS antibody

Cytokeratin, pan (Epithelial Marker); Clone PAN-CK (Concentrate)

RA0430-C.5 0.5 ml
EUR 360

H3 Pan Antibody

6806-50
EUR 379.2

LDH Pan antibody

10-1335 1 mg
EUR 310.8
Description: Mouse monoclonal LDH Pan antibody

LDH Pan antibody

10-1336 1 mg
EUR 310.8
Description: Mouse monoclonal LDH Pan antibody

SSX pan antibody

70R-50426 100 ul
EUR 292.8
Description: Purified Polyclonal SSX pan antibody

FOXO1 pan antibody

70R-37057 100 ug
EUR 392.4
Description: Rabbit Polyclonal FOXO1 pan antibody

PKC pan antibody

70R-33408 100 ug
EUR 392.4
Description: Rabbit polyclonal PKC pan antibody

NBPF pan antibody

70R-51031 100 ul
EUR 292.8
Description: Purified Polyclonal NBPF pan antibody

Synuclein pan antibody

70R-30766 100 ug
EUR 392.4
Description: Rabbit polyclonal Synuclein pan antibody

Actin pan antibody

70R-31095 100 ug
EUR 392.4
Description: Rabbit polyclonal Actin pan antibody

pan-AKT antibody

38602-100ul 100ul
EUR 302.4

Pan-Cadherin Antibody

48907-100ul 100ul
EUR 399.6

Pan-Cadherin Antibody

48907-50ul 50ul
EUR 286.8

pan Cadherin Antibody

45029-100ul 100ul
EUR 302.4

pan Cadherin Antibody

45029-50ul 50ul
EUR 224.4

pan Cadherin Antibody

45052-100ul 100ul
EUR 302.4

pan Cadherin Antibody

45052-50ul 50ul
EUR 224.4

pan-AKT Antibody

36716-100ul 100ul
EUR 302.4

pan CDH Antibody

37301-100ul 100ul
EUR 302.4

Keratin pan antibody

20R-2530 250 uL
EUR 612
Description: Rabbit polyclonal Keratin pan antibody

Synuclein-pan Antibody

33495-100ul 100ul
EUR 302.4

Synuclein-pan Antibody

33495-50ul 50ul
EUR 224.4

Actin-pan Antibody

33321-100ul 100ul
EUR 302.4

Actin-pan Antibody

33321-50ul 50ul
EUR 224.4

pan Endothelium antibody

10R-6386 100 ug
EUR 340.8
Description: Mouse monoclonal pan Endothelium antibody

pan Cadherin antibody

10R-7890 100 ug
EUR 386.4
Description: Mouse monoclonal pan Cadherin antibody

Actin-pan antibody

10R-A106a 100 ug
EUR 663.6
Description: Mouse monoclonal Actin-pan antibody

pan Cytokeratin antibody

10R-2060 100 ul
EUR 483.6
Description: Mouse monoclonal pan Cytokeratin antibody

Cytokeratin Pan antibody

10R-2096 100 ul
EUR 483.6
Description: Mouse monoclonal Cytokeratin Pan antibody

pan Keratin antibody

10R-2442 50 ug
EUR 486
Description: Mouse monoclonal pan Keratin antibody

pan-Cytokeratin antibody

23032-100ul 100ul
EUR 468

pan Cadherin Antibody

20-abx149140
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

pan-AKT Antibody

20-abx002260
  • EUR 493.20
  • EUR 710.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

NBPF-pan Antibody

20-abx008107
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

SSX-pan Antibody

20-abx008681
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Pan-AKT Antibody

20-abx125375
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

Actin-pan Antibody

20-abx013019
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Synuclein-pan Antibody

20-abx013202
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Pan pLDH Antibody

abx023860-1mg 1 mg
EUR 410.4

Pan pLDH Antibody

abx023861-1mg 1 mg
EUR 410.4

Pan SUMO Antibody

abx027085-400ul 400 ul
EUR 627.6

Pan SUMO Antibody

abx027085-80l 80 µl
EUR 343.2

Pan SUMO Antibody

abx027140-400ul 400 ul
EUR 627.6

Pan SUMO Antibody

abx027140-80l 80 µl
EUR 343.2

Actin- pan Antibody

ABF0115 100 ug
EUR 525.6

Actin- pan Antibody

ABF5288 100 ug
EUR 525.6

PKC- pan Antibody

ABF6197 100 ug
EUR 525.6

pan Cadherin Antibody

ABD2942 100 ug
EUR 525.6

pan- AKT Antibody

ABD7208 100 ug
EUR 525.6

pan Cadherin Antibody

ABD7514 100 ug
EUR 525.6

Pan myristoylation Antibody

20-abx322788
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Pan myristoylation Antibody

20-abx322789
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

pan Cadherin Antibody

abx217630-100ug 100 ug
EUR 526.8

Pan Ubiquitin Antibody

abx415347-50ug 50 ug
EUR 678

pan ADH Antibody

abx433090-200ul 200 ul
EUR 460.8

SHANK (pan) Antibody

abx440129-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx440140-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx442377-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx442388-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx442494-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx442658-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx442669-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx442775-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx442938-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx442949-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx443055-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx443218-100ug 100 ug
EUR 678

SAPAP (pan) Antibody

abx443229-100ug 100 ug
EUR 678

Ankyrin (pan) Antibody

abx443335-100ug 100 ug
EUR 678

SHANK (pan) Antibody

abx443499-100ug 100 ug
EUR 678

SAPAP (pan) Antibody

abx443510-100ug 100 ug
EUR 678

Ankyrin (pan) Antibody

abx443616-100ug 100 ug
EUR 678

SHANK (pan) Antibody

abx443780-100ug 100 ug
EUR 710.4

SAPAP (pan) Antibody

abx443791-100ug 100 ug
EUR 710.4

Ankyrin (pan) Antibody

abx443897-100ug 100 ug
EUR 710.4

SHANK (pan) Antibody

abx444061-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444072-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444178-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444342-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444353-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444459-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444623-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx444634-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx444740-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx444980-100ug 100 ug
EUR 627.6

SAPAP (pan) Antibody

abx444991-100ug 100 ug
EUR 627.6

GRK (pan) Antibody

abx445060-100ug 100 ug
EUR 627.6

QKI (pan) Antibody

abx445076-100ug 100 ug
EUR 627.6

Ankyrin (pan) Antibody

abx445097-100ug 100 ug
EUR 627.6

SHANK (pan) Antibody

abx440410-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx440421-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx440527-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx440691-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx440702-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx440808-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx440972-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx440983-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx441089-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx441253-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx441264-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx441370-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx441534-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx441545-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx441651-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx441815-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx441826-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx441932-100ug 100 ug
EUR 693.6

SHANK (pan) Antibody

abx442096-100ug 100 ug
EUR 693.6

SAPAP (pan) Antibody

abx442107-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx442213-100ug 100 ug
EUR 693.6

Ankyrin (pan) Antibody

abx440246-100ug 100 ug
EUR 693.6

Melanoma; Pan (Concentrate)

A00134-C 1 ml
EUR 811.2

Melanoma; Pan (Concentrate)

A00134-C.1 0.1 ml
EUR 165.6

Pan myristoylation Antibody

1-CSB-PA465729
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

Pan myristoylation Antibody

1-CSB-PA885152
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

pan Cadherin Antibody

DF2942 200ul
EUR 420

PKC-pan Antibody

AF6197 200ul
EUR 420

pan Actin Antibody

AF0115 200ul
EUR 420

pan Akt/KinaseB

MO15107 100 ug
EUR 522

NMDA NR1 Pan

MO25041 15 ug
EUR 710.4

Pan Keratin antibody

PAab09935 100 ug
EUR 463.2

anti-pan-Synuclein

LF-PA0194 100 ul
EUR 400.8
Description: Rabbit polyclonal to pan-Synuclein

PAN Indicator 0.1%

PAN0125 125ML
EUR 23.94

Ras-Related Protein R-Ras (RRAS) Antibody

20-abx123552
  • EUR 594.00
  • EUR 427.20
  • 100 ul
  • 50 ul

Ras-Related Protein M-Ras (MRAS) Antibody

20-abx113895
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-400ul 400 ul
EUR 627.6

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-80l 80 µl
EUR 343.2

Ras-related protein R-Ras (RRAS) Antibody

20-abx241995
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Protein

20-abx262883
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ras-related protein R-Ras (RRAS) Antibody

20-abx214133
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

abx237489-100ug 100 ug
EUR 610.8

XTT CELL VIABILITY ASSAY KIT (1000 ASSAY)

30007 1KIT
EUR 283.2
Description: Minimum order quantity: 1 unit of 1KIT

Related Ras Viral (R-Ras) Oncogene Homolog Antibody

20-abx115121
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Monoclonal Cytokeratin, pan (Epithelial Marker) Antibody, Clone: PAN-CK (Cocktail)

APR14636G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human Cytokeratin, pan (Epithelial Marker). The antibodies are raised in Mouse and are from clone PAN-CK (Cocktail). This antibody is applicable in WB, IHC and IF, FC

Endothelial Tube Formation Assay (In Vitro Angiogenesis Assay)

CBA-200 50 assays
EUR 672
Description: For angiogenesis to occur, endothelial cells must escape their stable location and break through the basement membrane. Cells migrate toward an angiogenic stimulus that may be released from nearby tumor cells. These cells proliferate to form new blood vessels. Our Endothelial Tube Formation Assay (In Vitro Angiogenesis) provides an easy, robust system to assess angiogenesis in vitro. The ECM gel matrix very closely resembles an in vivo environment.

R Ras antibody

10R-8533 100 ul
EUR 471.6
Description: Mouse monoclonal R Ras antibody

k-ras Antibody

39351-100ul 100ul
EUR 468

Ras-GRF1 Antibody

33147-100ul 100ul
EUR 302.4

Ras-GRF1 Antibody

33147-50ul 50ul
EUR 224.4

H-Ras antibody

22615-100ul 100ul
EUR 468

KappaB ras Antibody

24150-100ul 100ul
EUR 468

KappaB ras Antibody

2491-002mg 0.02 mg
EUR 206.18
Description: KappaB ras Antibody: KappaB ras-1 (κB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IκB (IκB), an inhibitor of the transcription factor NF-κB. IκB exists in two homologous forms, IκB-alpha and IκB-beta, although IκB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IκB-alpha-NF-κB complexes can shuttle in and out of the nucleus, IκB-beta-NF-κB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IκB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IκB-beta and regulating the rate of degradation of IκB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.

KappaB ras Antibody

2491-01mg 0.1 mg
EUR 523.7
Description: KappaB ras Antibody: KappaB ras-1 (κB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IκB (IκB), an inhibitor of the transcription factor NF-κB. IκB exists in two homologous forms, IκB-alpha and IκB-beta, although IκB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IκB-alpha-NF-κB complexes can shuttle in and out of the nucleus, IκB-beta-NF-κB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IκB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IκB-beta and regulating the rate of degradation of IκB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.

KappaB ras Peptide

2491P 0.05 mg
EUR 197.7
Description: (IN) KappaB ras peptide

H-Ras Antibody

abx140239-01mg 0.1 mg
EUR 460.8

H-Ras Antibody

20-abx141439
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Ras-GRF1 Antibody

20-abx012796
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

k-ras Antibody

abx037582-100ug 100 ug
EUR 469.2

Ras Rabbit mAb

A4735-100ul 100 ul
EUR 492

 

Immunobiology and Software of Aloe Vera-Based mostly Scaffolds in Tissue Engineering

Aloe vera (AV), a succulent plant belonging to the Liliaceae household, has been broadly used for biomedical and pharmaceutical software. Its recognition stems from a number of of its bioactive elements which have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory results.

Given such distinctive multi-modal organic impression, AV has been thought of as a biomaterial for regenerative drugs and tissue engineering functions, the place tissue restore and neo-angiogenesis are important.

This assessment outlines the rising scientific proof that demonstrates the benefit of AV as tissue engineering scaffolds. We significantly spotlight the latest advances within the software of AV-based scaffolds.

From a tissue engineering perspective, it’s pivotal that the implanted scaffolds strike an acceptable overseas physique response to be well-accepted within the physique with out problems. Herein, we spotlight the important thing mobile processes that regulate the overseas physique response to implanted scaffolds and underline the immunomodulatory results incurred by AV on the innate and adaptive system.

Provided that AV has a number of helpful elements, we focus on the significance of delving deeper into uncovering its motion mechanism and thereby bettering materials design methods for higher tissue engineering constructs for biomedical functions.

Immunobiology of Thymic Epithelial Tumors: Implications for Immunotherapy with Immune Checkpoint Inhibitors

Thymic epithelial tumors (TETs) are a bunch of uncommon thoracic malignancies, together with thymic carcinomas (TC) and thymomas (Tm). Autoimmune paraneoplastic illnesses are sometimes noticed in TETs, particularly Tms.

  • Up to now, chemotherapy continues to be the usual remedy for superior illness. Sadly, few therapeutic choices can be found for relapsed/refractory TETs.
  • In the previous few years, the deepening of information on thymus’ immunobiology and concerned altered genetic pathways have laid the muse for brand spanking new remedy choices in these uncommon neoplasms.
  • Lately, the immunotherapy revolution has landed in TETs, exhibiting each a darkish and lightweight facet. Certainly, regardless of the survival profit, the incidence of extreme autoimmune treatment-related antagonistic occasions has risen crescent uncertainty in regards to the feasibility of immunotherapy in these sufferers, susceptible to autoimmunity for his or her most cancers biology.
  • On this assessment, after summarizing immunobiology and immunopathology of TETs, we focus on accessible information on immune-checkpoint inhibitors and future views of this therapeutic technique.

6X His tag monoclonal antibody

FNSA-0019 500 uL
EUR 409.68
Description: 6X His tag monoclonal antibody secondary antibody

Tetrodotoxin (TTX) ELISA Test Kit

DEIANJ48 96T
EUR 1950
Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish.

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1332

PDHE2 protein (GST tag) (His tag)

80-1378 1 mg
EUR 678
Description: PDHE2 protein (GST tag) (His tag)

SLA protein (GST tag) (His tag)

80-1380 1 mg
EUR 716.4
Description: Purified recombinant SLA protein (GST tag) (His tag)

TROVE2 protein (GST tag) (His tag)

80-1383 1 mg
EUR 742.8
Description: Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag)

Frit Kit

FRIT-KIT 1each
EUR 148.8
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Column Packing Kit

PACK-KIT 1pack
EUR 1242
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

His-tag Purification Kit

abx299036-4U 4 U
EUR 427.2

DYKDDDDK-Tag Protein ELISA Kit

E4700-100
EUR 523.2

Porcine Parvovirus Antibody Elisa Test Kit

767-LSY-30009 192 Wells/kit
EUR 382

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 319.2

FERR ( Ferritin) ELISA test

7 96T/Box Ask for price
Description: ELISA based test for quantitative detection of FERR ( Ferritin)

Syphilis Antibody ELISA test

100 96T/Box Ask for price
Description: ELISA based test for quantitative detection of Syphilis Antibody

TSH (Thyrotrophin) ELISA test

14 96T/Box Ask for price
Description: ELISA based test for quantitative detection of TSH (Thyrotrophin)

PRL (Prolactin) ELISA test

4 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PRL (Prolactin)

E2 (Estradiol) ELISA test

5 96T/Box Ask for price
Description: ELISA based test for quantitative detection of E2 (Estradiol)

PROG (Progesterone) ELISA test

20 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PROG (Progesterone)

TESTO (Testosterone) ELISA test

19 96T/Box Ask for price
Description: ELISA based test for quantitative detection of O (osterone)

T3 (Triiodothyronine) ELISA test

15 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T3 (Triiodothyronine)

T4 (Thyroxine) ELISA test

16 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T4 (Thyroxine)

CA72-4 ELISA test

24 96T/Box Ask for price
Description: ELISA based test for quantitative detection of CA72-4

HBcAb Sandwich ELISA test

95 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HBcAb Sandwich

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-20tests 20 tests
EUR 283.2
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-40tests 40 tests
EUR 385.2
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Melamine Rapid Test Kit

abx092011-50tests 50 tests
EUR 444

NDV rapid test kit

RG15-03 1 box
EUR 166.86
Description: Please check the datasheet of NDV rapid test kit before using the test.

Staphyloslide Latex Test Kit

240915 PK100
EUR 272.46

Hach Test Kit CYANIDE

LCK315 EACH
EUR 144.28

Hach Test Kit FLUORIDE

LCK323 EACH
EUR 136.62

Hach Test Kit COPPER

LCK329 EACH
EUR 178.75

Hach Test Kit NICKEL

LCK337 EACH
EUR 183.86

Hach Test Kit SULPHIDE

LCK653 EACH
EUR 163.43

Elga Chlorine Test Kit

WAT4098 EACH
EUR 385.32

PGPEP1 protein (His tag)

30R-2903 100 ug
EUR 386.4
Description: Purified recombinant Human PGPEP1 protein (His tag)

PARD6B protein (His tag)

30R-2904 20 ug
EUR 386.4
Description: Purified recombinant Human PARD6B protein (His tag)

CHMP1A protein (His tag)

30R-2905 20 ug
EUR 386.4
Description: Purified recombinant Human CHMP1A protein (His tag)

TNFRSF17 protein (His tag)

30R-2906 100 ug
EUR 386.4
Description: Purified recombinant Human TNFRSF17 protein (His tag)

POLR2E protein (His tag)

30R-2907 100 ug
EUR 386.4
Description: Purified recombinant Human POLR2E protein (His tag)

RWDD1 protein (His tag)

30R-2908 50 ug
EUR 508.8
Description: Purified recombinant Human RWDD1 protein (His tag)

EPCAM protein (His tag)

30R-2909 100 ug
EUR 418.8
Description: Purified recombinant Human EPCAM protein (His tag)

NTS protein (His tag)

30R-2910 100 ug
EUR 386.4
Description: Purified recombinant Human NTS protein (His tag)

UXT protein (His tag)

30R-2911 100 ug
EUR 386.4
Description: Purified recombinant Human UXT protein (His tag)

SMUG1 protein (His tag)

30R-2912 100 ug
EUR 386.4
Description: Purified recombinant Human SMUG1 protein (His tag)

GLTP protein (His tag)

30R-2913 50 ug
EUR 386.4
Description: Purified recombinant Human GLTP protein (His tag)

RP9 protein (His tag)

30R-2914 100 ug
EUR 418.8
Description: Purified recombinant Human RP9 protein (His tag)

TYW5 protein (His tag)

30R-2915 100 ug
EUR 386.4
Description: Purified recombinant Human TYW5 protein (His tag)

HEBP1 protein (His tag)

30R-2916 50 ug
EUR 508.8
Description: Purified recombinant Human HEBP1 protein (His tag)

CD3E protein (His tag)

30R-2917 50 ug
EUR 386.4
Description: Purified recombinant Human CD3E protein (His tag)

BCL7A protein (His tag)

30R-2918 20 ug
EUR 386.4
Description: Purified recombinant Human BCL7A protein (His tag)

MED20 protein (His tag)

30R-2919 100 ug
EUR 386.4
Description: Purified recombinant Human MED20 protein (His tag)

UFSP1 protein (His tag)

30R-2920 50 ug
EUR 508.8
Description: Purified recombinant Human UFSP1 protein (His tag)

BCL2L10 protein (His tag)

30R-2921 100 ug
EUR 386.4
Description: Purified recombinant Human BCL2L10 protein (His tag)

CALML3 protein (His tag)

30R-2922 100 ug
EUR 386.4
Description: Purified recombinant Human CALML3 protein (His tag)

AMELX protein (His tag)

30R-2923 20 ug
EUR 386.4
Description: Purified recombinant Human AMELX protein (His tag)

MPST protein (His tag)

30R-2924 100 ug
EUR 386.4
Description: Purified recombinant Human MPST protein (His tag)

VBP1 protein (His tag)

30R-2925 100 ug
EUR 386.4
Description: Purified recombinant Human VBP1 protein (His tag)

GFER protein (His tag)

30R-2926 50 ug
EUR 386.4
Description: Purified recombinant Human GFER protein (His tag)

RLN2 protein (His tag)

30R-2927 100 ug
EUR 386.4
Description: Purified recombinant Human RLN2 protein (His tag)

ESM1 protein (His tag)

30R-2928 100 ug
EUR 386.4
Description: Purified recombinant Human ESM1 protein (His tag)

LSM12 protein (His tag)

30R-2929 20 ug
EUR 386.4
Description: Purified recombinant Human LSM12 protein (His tag)

AMN protein (His tag)

30R-2930 10 ug
EUR 386.4
Description: Purified recombinant Human AMN protein (His tag)

COX5A protein (His tag)

30R-2931 100 ug
EUR 386.4
Description: Purified recombinant Human COX5A protein (His tag)

CDK2AP2 protein (His tag)

30R-2932 100 ug
EUR 386.4
Description: Purified recombinant Human CDK2AP2 protein (His tag)

HFE protein (His tag)

30R-2933 100 ug
EUR 418.8
Description: Purified recombinant Human HFE protein (His tag)

BTF3 protein (His tag)

30R-2934 20 ug
EUR 386.4
Description: Purified recombinant Human BTF3 protein (His tag)

RSG1 protein (His tag)

30R-2935 10 ug
EUR 386.4
Description: Purified recombinant Human RSG1 protein (His tag)

CD247 protein (His tag)

30R-2936 50 ug
EUR 386.4
Description: Purified recombinant Human CD247 protein (His tag)

IFNA7 protein (His tag)

30R-2937 50 ug
EUR 386.4
Description: Purified recombinant Human IFNA7 protein (His tag)

JAM2 protein (His tag)

30R-2938 100 ug
EUR 386.4
Description: Purified recombinant Human JAM2 protein (His tag)

HAVCR2 protein (His tag)

30R-2939 100 ug
EUR 418.8
Description: Purified recombinant Human HAVCR2 protein (His tag)

XRCC3 protein (His tag)

30R-2940 100 ug
EUR 386.4
Description: Purified recombinant Human XRCC3 protein (His tag)

CFD protein (His tag)

30R-2941 100 ug
EUR 386.4
Description: Purified recombinant Human CFD protein (His tag)

CD2 protein (His tag)

30R-2942 100 ug
EUR 386.4
Description: Purified recombinant Human CD2 protein (His tag)

TAC1 protein (His tag)

30R-2943 100 ug
EUR 386.4
Description: Purified recombinant Human TAC1 protein (His tag)

FDCSP protein (His tag)

30R-2944 100 ug
EUR 386.4
Description: Purified recombinant Human FDCSP protein (His tag)

NOP16 protein (His tag)

30R-2945 20 ug
EUR 386.4
Description: Purified recombinant Human NOP16 protein (His tag)

SLAMF1 protein (His tag)

30R-2947 20 ug
EUR 386.4
Description: Purified recombinant Human SLAMF1 protein (His tag)

FN3K protein (His tag)

30R-2948 50 ug
EUR 386.4
Description: Purified recombinant Human FN3K protein (His tag)

ARSG protein (His tag)

30R-2949 100 ug
EUR 386.4
Description: Purified recombinant Human ARSG protein (His tag)

KLRG1 protein (His tag)

30R-2950 50 ug
EUR 386.4
Description: Purified recombinant Human KLRG1 protein (His tag)

FRZB protein (His tag)

30R-2952 100 ug
EUR 386.4
Description: Purified recombinant Human FRZB protein (His tag)

IMPAD1 protein (His tag)

30R-2953 100 ug
EUR 386.4
Description: Purified recombinant Human IMPAD1 protein (His tag)

FASLG protein (His tag)

30R-2954 100 ug
EUR 386.4
Description: Purified recombinant Human FASLG protein (His tag)

STK17B protein (His tag)

30R-2955 20 ug
EUR 386.4
Description: Purified recombinant Human STK17B protein (His tag)

FN3KRP protein (His tag)

30R-2956 100 ug
EUR 386.4
Description: Purified recombinant Human FN3KRP protein (His tag)

KCTD15 protein (His tag)

30R-2957 100 ug
EUR 386.4
Description: Purified recombinant Human KCTD15 protein (His tag)

MYD88 protein (His tag)

30R-2958 100 ug
EUR 386.4
Description: Purified recombinant Human MYD88 protein (His tag)

AICDA protein (His tag)

30R-2959 100 ug
EUR 386.4
Description: Purified recombinant Human AICDA protein (His tag)

TBPL1 protein (His tag)

30R-2960 50 ug
EUR 386.4
Description: Purified recombinant Human TBPL1 protein (His tag)

POLR3F protein (His tag)

30R-2961 100 ug
EUR 386.4
Description: Purified recombinant Human POLR3F protein (His tag)

INHA protein (His tag)

30R-2962 50 ug
EUR 386.4
Description: Purified recombinant Human INHA protein (His tag)

LCAT protein (His tag)

30R-2963 100 ug
EUR 386.4
Description: Purified recombinant Human LCAT protein (His tag)

RPN2 protein (His tag)

30R-2964 100 ug
EUR 508.8
Description: Purified recombinant Human RPN2 protein (His tag)

SDHAF2 protein (His tag)

30R-2965 100 ug
EUR 386.4
Description: Purified recombinant Human SDHAF2 protein (His tag)

CLEC2B protein (His tag)

30R-2966 100 ug
EUR 386.4
Description: Purified recombinant Human CLEC2B protein (His tag)

UPK2 protein (His tag)

30R-2967 100 ug
EUR 386.4
Description: Purified recombinant Human UPK2 protein (His tag)

GALT protein (His tag)

30R-2968 20 ug
EUR 386.4
Description: Purified recombinant Human GALT protein (His tag)

SOSTDC1 protein (His tag)

30R-2969 100 ug
EUR 418.8
Description: Purified recombinant Human SOSTDC1 protein (His tag)

PYCRL protein (His tag)

30R-2970 50 ug
EUR 508.8
Description: Purified recombinant Human PYCRL protein (His tag)

BPIFA1 protein (His tag)

30R-2972 100 ug
EUR 386.4
Description: Purified recombinant Human BPIFA1 protein (His tag)

SAMD13 protein (His tag)

30R-2973 100 ug
EUR 386.4
Description: Purified recombinant Human SAMD13 protein (His tag)

SAR1B protein (His tag)

30R-2974 100 ug
EUR 386.4
Description: Purified recombinant Human SAR1B protein (His tag)

BOLA1 protein (His tag)

30R-2975 100 ug
EUR 386.4
Description: Purified recombinant Human BOLA1 protein (His tag)

DNAJB4 protein (His tag)

30R-2976 50 ug
EUR 386.4
Description: Purified recombinant Human DNAJB4 protein (His tag)

LDHA protein (His tag)

30R-3166 50 ug
EUR 308.4
Description: Purified recombinant LDHA protein (His tag)

Adiponectin protein (His tag)

30R-3195 50 ug
EUR 308.4
Description: Purified recombinant Adiponectin protein

Adiponectin protein (His tag)

30R-3205 50 ug
EUR 308.4
Description: Purified recombinant Adiponectin protein

PIGF1 protein (His Tag)

30R-AP011 20 ug
EUR 897.6
Description: Purified recombinant Human PIGF1 protein (His Tag)

Myostatin, His-Tag Protein

20-abx262128
  • EUR 393.60
  • EUR 6156.00
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

EBNA1 protein (His tag)

80-1340 100 ug
EUR 289.2
Description: Purified recombinant EBNA1 protein (His tag)

ompP2 protein (His tag)

80-1349 100 ug
EUR 289.2
Description: Purified recombinant ompP2 protein (His tag)

GARS protein (His tag)

80-1374 1 mg
EUR 678
Description: Purified recombinant GARS/GlyRS protein (His tag)

JO1 protein (His tag)

80-1375 1 mg
EUR 678
Description: Purified recombinant JO1 protein (His tag)

IARS protein (His tag)

80-1377 1 mg
EUR 2544
Description: Purified recombinant IARS (OJ) protein (His tag)

tTG protein (His tag)

80-1379 1 mg
EUR 703.2
Description: Purified recombinant tTG protein (His tag)

PSIP1 protein (His tag)

80-1381 1 mg
EUR 2103.6
Description: Purified recombinant PSIP1 (DSF70) protein (His tag)

TPO protein (His tag)

80-1382 1 mg
EUR 1532.4
Description: Purified recombinant TPO protein (His tag)

TRIM21 protein (His tag)

80-1385 1 mg
EUR 678
Description: Purified recombinant TRIM21 (Ro52) protein (His tag)

TG3 protein (His tag)

80-1386 1 mg
EUR 1585.2
Description: Purified recombinant Transglutaminase 3 (TG3) protein (His tag)

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